Social support, stress, health locus of control, active and avoidance coping, and depression were studied with 107 married couples in which one partner had a chronic obstructive airway disease (mean age = 62 years old). Differences between couples were evident when gender of the patient was assessed. Female patient couples that were older appeared more at risk than male patient couples for distress. In the analyses of spouse depression, gender moderated the relation of coping, social support, and health locus of control with depression. For patients, coping and social support were directly related to depression rather than moderated by gender. Implications for prevention and future research are discussed.