Coexpression of interleukin-8 receptors in head and neck squamous cell carcinoma

Am J Surg. 1997 Nov;174(5):507-12. doi: 10.1016/s0002-9610(97)00165-7.


Background: Interleukin 8 (IL-8) is an important cytokine involved in tumor growth and angiogenesis in a variety of malignancies. We hypothesize that IL-8 plays an important role in the cellular proliferation and angiogenesis seen in head and neck squamous cell carcinoma (HNSCC) and set out to identify its receptors, IL-8RA and IL-8RB.

Methods: Immunohistochemical analysis was performed on specimens from 38 HNSCC patients with stage I to IV disease and control tissues.

Results: All of cancer specimens demonstrated positive staining for IL-8RA. The IL-8RA staining of microvessel endothelial cells was seen in 51%. The IL-8RB pattern was similar to the IL-8RA pattern in that 97% of cancer sections demonstrated positive cancer cell staining, and 74% of the specimens demonstrated positive staining for microvessel endothelial cells.

Conclusion: Our studies demonstrate that IL-8 receptors are expressed by cancer cells and microvessel endothelial cells in HNSCC, suggesting that IL-8 may act in an autocrine/paracrine fashion to stimulate cellular proliferation and angiogenesis.

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis*
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology
  • Head and Neck Neoplasms / metabolism*
  • Head and Neck Neoplasms / pathology
  • Humans
  • Immunohistochemistry
  • Interleukin-8 / biosynthesis*
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Receptors, Chemokine / biosynthesis
  • Receptors, Interleukin / biosynthesis*
  • Receptors, Interleukin-8A
  • Receptors, Interleukin-8B
  • Transplantation, Heterologous


  • Antigens, CD
  • Interleukin-8
  • Receptors, Chemokine
  • Receptors, Interleukin
  • Receptors, Interleukin-8A
  • Receptors, Interleukin-8B