Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes

Acta Ophthalmol Scand. 1997 Aug;75(4):412-5. doi: 10.1111/j.1600-0420.1997.tb00401.x.


Purpose: To examine if different dose regimens of latanoprost cause a difference in daytime intraocular pressure (IOP) in normal eyes and if such changes could be attributed to an increase in aqueous flow.

Methods: In a randomised, open, cross-over study latanoprost 50 microg/ml was instilled in one eye of 18 volunteers. Three dose regimens (one/three drops once daily or one drop twice daily) were evaluated. IOP was measured at the end of each 14-day treatment period. Aqueous flow and endothelial permeability were assessed by fluorophotometry.

Results: All dose regimens reduced IOP significantly (p < 0.001). Once daily applications reduced IOP more than twice daily (p < 0.01). No statistically significant difference in aqueous flow was detected between different treatments. One drop daily increased aqueous flow compared with control eyes (p < 0.05). A similar, but not statistically significant tendency was present with the other regimens. Corneal endothelial permeability was not affected.

Conclusion: Once daily applications of latanoprost reduce IOP more effectively than twice daily in normal subjects. This cannot be explained by an increase in aqueous flow.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aqueous Humor / drug effects*
  • Aqueous Humor / physiology
  • Cross-Over Studies
  • Drug Administration Schedule
  • Endothelium, Corneal / metabolism
  • Female
  • Fluorophotometry
  • Humans
  • Intraocular Pressure / drug effects*
  • Latanoprost
  • Male
  • Permeability
  • Prostaglandins F, Synthetic / administration & dosage*
  • Prostaglandins F, Synthetic / adverse effects
  • Prostaglandins F, Synthetic / pharmacology


  • Prostaglandins F, Synthetic
  • Latanoprost