The treatment of steroid-induced bone loss in transplantation

Curr Opin Nephrol Hypertens. 1997 Nov;6(6):544-9. doi: 10.1097/00041552-199711000-00008.

Abstract

Osteopenia after transplantation is a significant cause of morbidity. Despite the lack of randomized, placebo-controlled trials in renal transplantation, there is literature supporting both the prevention and treatment of existing corticosteroid-induced osteoporosis with antiresorptive agents, such as calcitonin and bisphosphonates. The newer pharmacologic agents, nasal spray calcitonin and alendronate, have shown promising results in postmenopausal osteoporosis, and their ease of administration and low incidence of side effects make them ideal for renal transplant patients.

Publication types

  • Review

MeSH terms

  • Bone Diseases, Metabolic / etiology
  • Bone Diseases, Metabolic / therapy*
  • Female
  • Humans
  • Kidney Transplantation*
  • Steroids / adverse effects*

Substances

  • Steroids