Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

J Rheumatol. 1997 Nov;24(11):2221-4.


Objective: To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM).

Methods: HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age.

Results: HA serum levels (mean microg/l +/- SEM) were 41 +/- 8.7 in healthy controls; 113 +/- 15.9 in RA: and 420 +/- 26 in FM.

Conclusion: HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / blood
  • Biomarkers / blood
  • Female
  • Fibromyalgia / blood*
  • Humans
  • Hyaluronic Acid / blood*
  • Middle Aged
  • Sensitivity and Specificity


  • Biomarkers
  • Hyaluronic Acid