Abstract
Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine Vbeta8(+) T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of Vbeta8(+) cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Cell Adhesion
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Cell Movement
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Enterotoxins / immunology
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Hyaluronan Receptors / metabolism*
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Hyaluronic Acid / metabolism
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Ligands
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Lymph Nodes / cytology
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Lymph Nodes / immunology
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Lymphocyte Activation*
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Mice
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Mice, Inbred BALB C
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Peritoneal Cavity / cytology
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Peritonitis / immunology*
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Receptors, Antigen, T-Cell / analysis*
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Receptors, Antigen, T-Cell, alpha-beta*
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Superantigens / immunology
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / physiology*
Substances
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Antibodies, Monoclonal
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Enterotoxins
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Hyaluronan Receptors
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Ligands
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Receptors, Antigen, T-Cell
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Receptors, Antigen, T-Cell, alpha-beta
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Superantigens
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T cell receptor Vbeta8
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enterotoxin B, staphylococcal
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Hyaluronic Acid