Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent

Ann Neurol. 1997 Oct;42(4):659-61. doi: 10.1002/ana.410420418.


As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon3/epsilon3 genotype, but the OR for AD with the epsilon3/epsilon4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon4 and AD is weaker in African Americans than in whites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group / genetics*
  • Aged
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / ethnology*
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / genetics*
  • Female
  • Genotype
  • Humans
  • Incidence
  • Male
  • Prevalence
  • Risk Factors
  • United States


  • Apolipoproteins E