Abstract
Recent experiments with Kuzbanian, a disintegrin metalloprotease that is required during development for lateral inhibitory signaling, suggest that signaling molecules of the Notch family may guide cell fate only after they are activated by proteolysis, and that the proteolysis may be catalyzed by Kuzbanian.
MeSH terms
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Disintegrins / genetics
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Disintegrins / metabolism
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Disintegrins / physiology*
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Drosophila Proteins*
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Gene Expression Regulation, Developmental
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Hydrolysis
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Membrane Proteins / genetics
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Membrane Proteins / metabolism
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Membrane Proteins / physiology*
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Metalloendopeptidases / genetics
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Metalloendopeptidases / metabolism
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Metalloendopeptidases / physiology*
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Receptors, Notch
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Signal Transduction* / genetics
Substances
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Disintegrins
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Drosophila Proteins
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Membrane Proteins
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Receptors, Notch
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KUZ protein, Drosophila
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Metalloendopeptidases