Developmental signaling: notch signals Kuz it's cleaved

Curr Biol. 1997 Nov 1;7(11):R716-20. doi: 10.1016/s0960-9822(06)00364-2.

Abstract

Recent experiments with Kuzbanian, a disintegrin metalloprotease that is required during development for lateral inhibitory signaling, suggest that signaling molecules of the Notch family may guide cell fate only after they are activated by proteolysis, and that the proteolysis may be catalyzed by Kuzbanian.

Publication types

  • Review

MeSH terms

  • Disintegrins / genetics
  • Disintegrins / metabolism
  • Disintegrins / physiology*
  • Drosophila Proteins*
  • Gene Expression Regulation, Developmental
  • Hydrolysis
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Metalloendopeptidases / genetics
  • Metalloendopeptidases / metabolism
  • Metalloendopeptidases / physiology*
  • Receptors, Notch
  • Signal Transduction* / genetics

Substances

  • Disintegrins
  • Drosophila Proteins
  • Membrane Proteins
  • Receptors, Notch
  • KUZ protein, Drosophila
  • Metalloendopeptidases