PDZ domain proteins: scaffolds for signaling complexes

Curr Biol. 1997 Dec 1;7(12):R770-3. doi: 10.1016/s0960-9822(06)00401-5.


InaD, a Drosophila photoreceptor scaffolding protein, assembles multiple signal-transducing proteins at the membrane via its five PDZ domains, enhancing speed and efficiency of vision. Extensive conservation of PDZ domains suggests that these motifs have a general role in organizing diverse signaling complexes.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Calcium Channels / metabolism
  • Drosophila
  • Drosophila Proteins*
  • Eye Proteins / metabolism*
  • GTP-Binding Proteins / metabolism
  • Photoreceptor Cells, Invertebrate / metabolism*
  • Protein Kinase C / metabolism
  • Signal Transduction*
  • TRPC Cation Channels
  • Type C Phospholipases / metabolism


  • Calcium Channels
  • Drosophila Proteins
  • Eye Proteins
  • TRPC Cation Channels
  • inaD protein, Drosophila
  • transient receptor potential cation channel, subfamily C, member 1
  • Protein Kinase C
  • Type C Phospholipases
  • GTP-Binding Proteins