A novel receptor for Apo2L/TRAIL contains a truncated death domain

Curr Biol. 1997 Dec 1;7(12):1003-6. doi: 10.1016/s0960-9822(06)00422-2.


Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [3-5]. By cross-hybridization with DcR1, we have identified a fourth Apo2L receptor, which contains a cytoplasmic region with a truncated death domain. We subsequently named this protein decoy receptor 2 (DcR2). The DcR2 gene mapped to human chromosome 8p21, as did the genes encoding DR4, DR5 and DcR1. A single DcR2 mRNA transcript showed a unique expression pattern in human tissues and was particularly abundant in fetal liver and adult testis. Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-kappaB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor.

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Apoptosis Regulatory Proteins
  • Apoptosis*
  • Base Sequence
  • Cell Line, Transformed
  • Chromosomes, Human, Pair 8
  • DNA, Complementary
  • HeLa Cells
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Molecular Sequence Data
  • Receptors, Tumor Necrosis Factor / chemistry*
  • Receptors, Tumor Necrosis Factor / genetics
  • Recombinant Fusion Proteins / chemistry
  • Recombinant Fusion Proteins / genetics
  • Sequence Homology, Amino Acid
  • TNF-Related Apoptosis-Inducing Ligand
  • Tumor Necrosis Factor-alpha / metabolism*
  • fas Receptor / metabolism


  • Apoptosis Regulatory Proteins
  • DNA, Complementary
  • Membrane Glycoproteins
  • Receptors, Tumor Necrosis Factor
  • Recombinant Fusion Proteins
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human
  • Tumor Necrosis Factor-alpha
  • fas Receptor

Associated data

  • GENBANK/AF147230