Abstract
The alpha/beta barrel enzyme phosphotriesterase from soil bacteria appears to have evolved the ability to hydrolyze the insecticide paraoxon at the diffusion limit in only a few decades. A newly-identified open reading frame from Escherichia coli may offer a clue to its origins.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Aryldialkylphosphatase
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Bacteria / enzymology*
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Bacteria / genetics
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Biological Evolution*
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Escherichia coli / genetics
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Escherichia coli / metabolism
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Esterases / biosynthesis*
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Esterases / chemistry
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Esterases / genetics
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Insecticides / metabolism*
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Molecular Sequence Data
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Open Reading Frames
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Paraoxon / metabolism*
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Soil Microbiology*
Substances
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Insecticides
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Esterases
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Aryldialkylphosphatase
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Paraoxon