New insights into proteasome function: from archaebacteria to drug development

Chem Biol. 1995 Aug;2(8):503-8. doi: 10.1016/1074-5521(95)90182-5.


The proteasome is not simply a 'garbage disposal unit' but also has functions in the control of the cell cycle and immune responses. The structure of an archaebacterial proteasome has recently been determined to high resolution, and provides insight into the unusual mechanism of proteolytic cleavage by the proteasome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Archaea / enzymology*
  • Archaea / metabolism
  • Archaea / ultrastructure
  • Drug Design
  • Endopeptidases / drug effects
  • Endopeptidases / metabolism
  • Endopeptidases / physiology*
  • Ubiquitins / antagonists & inhibitors
  • Ubiquitins / metabolism


  • Ubiquitins
  • Endopeptidases