Mitomycin C: small, fast and deadly (but very selective)

Chem Biol. 1995 Sep;2(9):575-9. doi: 10.1016/1074-5521(95)90120-5.

Abstract

Mitomycin C, an important antitumor drug and antibiotic, has an extraordinary ability to crosslink DNA with high efficiency and absolute specificity for the sequence CpG. Recent results have shown how mitomycin C crosslinks DNA, and why the sequence specificity is so complete. This new understanding may allow the design of agents that mimic mitomycin C's economy of structure and can crosslink other sequences.

Publication types

  • Review

MeSH terms

  • Antibiotics, Antineoplastic / chemistry*
  • Antibiotics, Antineoplastic / pharmacology*
  • Cross-Linking Reagents / chemistry
  • Cross-Linking Reagents / pharmacology
  • DNA / chemistry
  • DNA / drug effects
  • Mitomycin / chemistry*
  • Mitomycin / pharmacology*

Substances

  • Antibiotics, Antineoplastic
  • Cross-Linking Reagents
  • Mitomycin
  • DNA