Isolated right ventricle infarction is extremely rare, and its electrocardiographic (ECG) signs may be misinterpreted or even missed, especially when a typical clinical picture is lacking. This paper describes a case of isolated right ventricle infarction, recognized only by echocardiography. The patient presented with ST-segment elevation in left precordial leads together with minimal ST-segment elevation in inferior leads on a 12-lead ECG. Angiography revealed the culprit right coronary artery, which was small and nondominant. No significant obstructions were found in the left anterior descending artery. This case demonstrates that the ECG appearance of isolated right ventricle infarction may mimic anterior wall infarction and can be easily missed if not suspected.