Fiber-derived butyrate and the prevention of colon cancer

Chem Biol. 1997 Nov;4(11):783-9. doi: 10.1016/s1074-5521(97)90111-3.

Abstract

Inhibition of the enzyme histone deacetylase by butyrate results in the direct transcriptional upregulation of the cyclin-dependent kinase inhibitor p21/Cip1/WAF1. We discuss a small-molecule-mediated signaling pathway to explain the suspected anti-colon-cancer properties of fiber-derived butyrate.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Butyrates / therapeutic use*
  • Butyric Acid
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / prevention & control*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins / biosynthesis
  • DNA-Binding Proteins / metabolism
  • Dietary Fiber / therapeutic use*
  • Enzyme Inhibitors / therapeutic use*
  • Erythroid-Specific DNA-Binding Factors
  • Histone Deacetylase Inhibitors*
  • Humans
  • Signal Transduction
  • Transcription Factors / metabolism
  • Transcription, Genetic / drug effects
  • Tumor Cells, Cultured
  • Up-Regulation / drug effects

Substances

  • Butyrates
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • DNA-Binding Proteins
  • Dietary Fiber
  • Enzyme Inhibitors
  • Erythroid-Specific DNA-Binding Factors
  • Histone Deacetylase Inhibitors
  • Transcription Factors
  • Butyric Acid