Dynamic changes in gene expression during in vitro differentiation of mouse embryonic stem cells

Cytokines Mol Ther. 1995 Jun;1(2):139-43.


The expression pattern of protein tyrosine kinases (PTK) and phosphatases (PTP) was determined during the first eight days of in vitro differentiation of mouse embryonic stem (ES) cells. DNA fingerprinting of catalytic domains amplified from cDNA revealed dynamic changes in expression of previously described genes. A novel PTP is expressed in undifferentiated ES cells, and is down-regulated during in vitro differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Clone Cells
  • DNA Fingerprinting
  • Embryo, Mammalian
  • Gene Expression Regulation*
  • Mice
  • Polymerase Chain Reaction
  • Protein Tyrosine Phosphatases / biosynthesis*
  • Protein-Tyrosine Kinases / biosynthesis*
  • Stem Cells / cytology*
  • Stem Cells / enzymology*


  • Protein-Tyrosine Kinases
  • Protein Tyrosine Phosphatases