Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS

Lifetime Data Anal. 1995;1(1):35-47. doi: 10.1007/BF00985256.


Tree-structured methods for exploratory data analysis have previously been extended to right-censored survival data. We further extend these methods to allow for truncation and time-dependent covariates. We apply the new methods to a data set on incubation times of acquired immunodeficiency syndrome (AIDS), using calendar time as a time-dependent covariate. Contrary to expectation, we find that rates of progression to AIDS appear to be faster after August 1989 than before.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Disease Progression
  • HIV Seropositivity / epidemiology*
  • Humans
  • Male
  • Models, Statistical
  • Netherlands / epidemiology
  • New York / epidemiology
  • San Francisco / epidemiology
  • Survival Analysis*
  • Time Factors
  • Virus Latency*