Disturbances of autonomic nervous function in primary Sjögren's syndrome

Scand J Rheumatol. 1997;26(5):401-6. doi: 10.3109/03009749709065710.


Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjögren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p < 0.001, p < 0.05, p < 0.01, p < 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p< 0.001) as well as the BI (r = -0.60, p < 0.01). No correlations were found between the 3 autonomic nerve function parameters (E/I-ratio, AI, BI) and unstimulated whole sialometry or salivary gland scintigraphy. We conclude that autonomic disturbances, mainly affecting the parasympathetic nerves are associated with pSS.

Publication types

  • Corrected and Republished Article

MeSH terms

  • Adolescent
  • Adult
  • Autonomic Nervous System / physiopathology*
  • Blood Pressure / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radionuclide Imaging
  • Respiration / physiology
  • Salivary Glands / diagnostic imaging
  • Salivary Glands / physiology
  • Sjogren's Syndrome / physiopathology*
  • Tears / physiology
  • Tilt-Table Test