Iodised rapeseed oil for eradication of severe endemic goitre

Lancet. 1997 Nov 22;350(9090):1542-5. doi: 10.1016/s0140-6736(97)02427-6.


Iodised oil is traditionally based on the fatty acids (FAs) of the poppyseed, an expensive commodity. An equipotent but cheaper vehicle would be welcome. Iodination of rapeseed oil yields a product (Brassiodol) with a total iodine content of 376 mg/mL. Brassiodol has been compared with the poppyseed-based Lipiodol in two villages in Chad in the west African goitre belt. A 2 mL dose of Brassiodol is followed by urinary spillover of half the ingested iodine. The other half undergoes tissue sequestration and slow release, allowing protection against iodine deficiency for 9 months and regression of stage I/II goitre for longer than was achieved with Lipiodol. The prolonged protection offered by Brassiodol can be attributed to its unique lipid profile. The urinary output argues that 1 mL should not be exceeded, and at that dose the cost would be only 20 US cents per person per year.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brassica
  • Chad
  • Fatty Acids / metabolism
  • Fatty Acids, Monounsaturated
  • Female
  • Goiter, Endemic / etiology
  • Goiter, Endemic / prevention & control*
  • Humans
  • Iodine / deficiency
  • Iodine / urine
  • Iodized Oil / therapeutic use*
  • Male
  • Plant Oils / metabolism
  • Plant Oils / therapeutic use*
  • Rapeseed Oil
  • Thyroid Hormones / blood


  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Plant Oils
  • Rapeseed Oil
  • Thyroid Hormones
  • brassiodol
  • Iodized Oil
  • Iodine