Abstract
Apoptosis research has accelerated with the discovery of genes within a common cell death pathway and evidence for their inter-relationship. Breakthroughs include insights into the mechanism of action of the Bcl-2 family, caspases and their targets, and death receptor complexes. Deregulation of apoptosis is evident in tumors and viral infection, as well as in autoimmune disease, immunodeficiency, neurodegeneration, and infertility.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis / physiology*
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Autoimmune Diseases / pathology
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Autoimmune Diseases / physiopathology
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Cysteine Endopeptidases / metabolism
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Homeostasis / physiology*
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Humans
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Infertility
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Neoplasms / pathology
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Neoplasms / physiopathology
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Nerve Degeneration / pathology
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Nerve Degeneration / physiopathology
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Proto-Oncogene Proteins c-bcl-2 / metabolism
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Receptors, Cell Surface / physiology
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Virus Diseases / pathology
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Virus Diseases / physiopathology
Substances
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Proto-Oncogene Proteins c-bcl-2
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Receptors, Cell Surface
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Cysteine Endopeptidases