The lineage commitment of haemopoietic progenitor cells

Curr Opin Genet Dev. 1997 Oct;7(5):609-13. doi: 10.1016/s0959-437x(97)80007-x.


Multipotent haemopoietic progenitor cells appear to be 'primed' for commitment by co-expression of a multiplicity of genes characteristic of different lineages. Lineage commitment proceeds as the consolidation of a distinct pattern of gene expression out of this milieu.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Gene Expression Regulation*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology*
  • Humans
  • Models, Biological