Cellular diversification in the vertebrate retina

Curr Opin Genet Dev. 1997 Oct;7(5):651-8. doi: 10.1016/s0959-437x(97)80013-5.


The discovery of heterogeneous populations of retinal precursors with sequentially modified fates may help solve the conundrum of conserved histogenesis in the absence of determination either by birthdate or lineage. Combined with a wealth of new data on the exogenous and endogenous factors that influence cellular fate in the retina, models of how complexity is generated are beginning to emerge.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Embryonic Induction
  • Gene Expression Regulation, Developmental
  • Growth Substances / biosynthesis
  • Models, Biological
  • Morphogenesis
  • Nerve Growth Factors / biosynthesis
  • Retina / cytology*
  • Retina / embryology*
  • Stem Cells / cytology*
  • Stem Cells / physiology*
  • Transcription Factors / biosynthesis
  • Transcription, Genetic
  • Vertebrates
  • Visual Pathways / embryology
  • Visual Pathways / physiology


  • Growth Substances
  • Nerve Growth Factors
  • Transcription Factors