Low-dose aspirin for oocyte donation recipients with a thin endometrium: prospective, randomized study

Fertil Steril. 1997 Nov;68(5):927-30. doi: 10.1016/s0015-0282(97)00330-0.


Objective: To evaluate the effect of low-dose aspirin use in oocyte donation recipients with an endometrial thickness of < 8 mm.

Design: A prospective, randomized study.

Setting: An oocyte donation program in a private infertility practice.

Patient(s): Twenty-eight recipients undergoing oocyte donation who failed to develop an endometrial thickness of at least 8 mm in a previous evaluation cycle.

Intervention(s): Fifteen recipients received low-dose aspirin (81 mg/d) in addition to standard hormone replacement for an oocyte donation cycle. The remaining 13 recipients did not receive aspirin.

Main outcome measure(s): Clinical pregnancy rates, delivery rates, implantation rates, and change in endometrial thickness were compared in the aspirin and nonaspirin groups.

Result(s): There was no demonstrable increase in endometrial thickness in the aspirin-treated group. However, there was a statistically significant increase in implantation rates in the aspirin-treated group (24% versus 9%) and in implantation rates and clinical pregnancy rates in the aspirin-treated group when the final endometrial thickness was < 8 mm.

Conclusion(s): Low-dose aspirin therapy improves implantation rates in oocyte donation recipients with a thin endometrium.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aspirin / administration & dosage*
  • Aspirin / therapeutic use
  • Embryo Implantation
  • Embryo Transfer
  • Endometrium / pathology*
  • Female
  • Fertilization in Vitro
  • Humans
  • Infertility, Female / pathology*
  • Oocyte Donation*
  • Pregnancy
  • Pregnancy, Multiple
  • Prospective Studies


  • Aspirin