Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate

Neuron. 1997 Nov;19(5):1141-6. doi: 10.1016/s0896-6273(00)80404-3.

Abstract

Glutamate receptors of the kainate-preferring subtype have recently been shown to mediate synaptic transmission in the hippocampus. The low-affinity kainate receptor subunit GluR7 was found to be nonfunctional in previous studies. We report here that the GluR7 subunit and a novel carboxy-terminal splice variant, GluR7b, are functional glutamate receptors with unique pharmacological properties. In particular, glutamate exhibits a 10-fold lower potency for (non-desensitized) GluR7-mediated currents as compared to other non-NMDA receptor channels. These data will facilitate understanding of the distinct role played by GluR7 receptors in synaptic transmission.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Recombinant*
  • Genetic Variation / physiology*
  • Glutamic Acid / pharmacology*
  • Molecular Sequence Data
  • Rats
  • Receptors, Kainic Acid / drug effects*
  • Receptors, Kainic Acid / genetics*
  • Receptors, Kainic Acid / metabolism*

Substances

  • DNA, Recombinant
  • GluK3 kainate receptor
  • Receptors, Kainic Acid
  • Glutamic Acid

Associated data

  • GENBANK/AF027331