Hypoxic-ischemic cerebral injury in the full-term infant results in a variety of neurologic manifestations. The pathogenetic events resulting in this central nervous system injury may occur throughout the prenatal period. Several clinical patterns of signs and symptoms of hypoxic-ischemic cerebral injury have been identified in the term infant. Further, characteristic neuroradiologic patterns of this injury can be discerned. Information derived from the term infant's clinical course and neuroimaging data convey useful neurodevelopmental prognostic information. Several potential and promising therapeutic agents exist may attenuate the sequelae of hypoxic-ischemic cerebral injury to the term infant.