Risk for gastric lymphoma in persons with CagA+ and CagA- Helicobacter pylori infection

J Infect Dis. 1997 Dec;176(6):1641-4. doi: 10.1086/517346.


Infection with Helicobacter pylori increases the risk for gastric non-Hodgkin's lymphoma (GNHL). Strains that express CagA protein are thought to be particularly virulent. It was determined whether CagA+ H. pylori infection increased the risk for GNHL more than CagA infection. Thirty-two cases and 130 controls previously tested for H. pylori antibodies were tested for CagA antibodies by ELISA. The risk for GNHL was compared among CagA+, CagA-, and uninfected persons by use of conditional logistic regression. CagA+ subjects had 8.2 times the risk for GNHL than uninfected persons (95% confidence interval [CI], 2.5-26.7). CagA- subjects had 4.4 times the risk for GNHL than uninfected persons (95% CI, 1.2-16.5). Among infected subjects only, CagA+ infection was not associated with significantly increased risk for GNHL when compared with CagA- infection (odds ratio, 2.1; 95% CI, 0.8-5.4). This study does not support a major role for CagA in lymphomagenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Bacterial / blood
  • Antigens, Bacterial*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / immunology
  • Case-Control Studies
  • Female
  • Helicobacter Infections / complications
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology*
  • Helicobacter pylori / genetics*
  • Helicobacter pylori / immunology
  • Helicobacter pylori / pathogenicity
  • Humans
  • Lymphoma, Non-Hodgkin / etiology*
  • Lymphoma, Non-Hodgkin / microbiology
  • Male
  • Regression Analysis
  • Risk
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / microbiology


  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • cagA protein, Helicobacter pylori