Excretion of epidermal growth factor in human adult polycystic kidney disease

Isr J Med Sci. 1997 Oct;33(10):641-2.


In chronic renal failure, epidermal growth factor (EGF) excretion is decreased. In this study, asymptomatic adult polycystic kidney disease (APKD) patients with a relatively preserved glomerular filtration rate were examined. Excretion of EGF was studied in 6 patients with APKD (median age 42 years; serum creatinine [median] 95 [range-80-133] mumol/l) and compared with that of 28 healthy controls. EGF was determined in a spot morning urine by using a specific radioimmunoassay, and expressed in relation to creatinine excretion. Excretion of EGF in APKD was (median) 157 (range-13-359) and in the controls (median) 546 (range-238-1199) pmol/mmol creatinine (p < 0.001). Low excretion of EGF in APKD patients with preserved kidney function suggests a distal abnormality at an early stage of the disease, prior to the development of renal failure.

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Creatinine / urine
  • Epidermal Growth Factor / physiology
  • Epidermal Growth Factor / urine*
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Kidney Failure, Chronic / etiology
  • Kidney Tubules, Distal / physiopathology
  • Male
  • Middle Aged
  • Polycystic Kidney Diseases / complications
  • Polycystic Kidney Diseases / physiopathology
  • Polycystic Kidney Diseases / urine*
  • Radioimmunoassay


  • Epidermal Growth Factor
  • Creatinine