Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

Hepatology. 1997 Dec;26(6):1667-77. doi: 10.1002/hep.510260641.


The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anion Transport Proteins
  • Anions / metabolism
  • Bile Acids and Salts / metabolism
  • Bile Acids and Salts / physiology
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cloning, Molecular
  • Humans
  • Liver / metabolism*
  • Membrane Transport Proteins*
  • Models, Molecular
  • Organic Anion Transporters, Sodium-Dependent
  • Rats
  • Substrate Specificity
  • Symporters


  • Anion Transport Proteins
  • Anions
  • Bile Acids and Salts
  • Carrier Proteins
  • Membrane Transport Proteins
  • Organic Anion Transporters, Sodium-Dependent
  • Symporters
  • sodium-bile acid cotransporter