Analysis of E2 Amino Acid Variants of Human Papillomavirus Types 16 and 18 and Their Associations With Lesion Grade and HLA DR/DQ Type

Int J Cancer. 1997 Nov 27;73(5):651-5. doi: 10.1002/(sici)1097-0215(19971127)73:5<651::aid-ijc7>3.0.co;2-w.

Abstract

Human papillomavirus (HPV) 16 and HPV 18 E2 amino acid variants and host HLA DR/DQ haplotypes have been identified by direct nucleic acid sequencing from cervical scrapes. HPV16 E2 variants co-segregate with a nucleotide variant at nt350 (in E6), which previously has been associated with persistent infections. Both HPV16 and HPV18 E2 variants occur relatively more frequently in individuals with HLA DR/DQ haplotypes 0401/0301 and 1101/0301 but are not related to lesion grade.

MeSH terms

  • Amino Acids / genetics
  • Base Sequence
  • Cervix Uteri / pathology
  • Cervix Uteri / virology
  • DNA Primers / chemistry
  • DNA, Viral / analysis
  • DNA-Binding Proteins*
  • Female
  • Genetic Variation / genetics
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Molecular Sequence Data
  • Oncogene Proteins, Viral / genetics*
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / genetics*
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / virology
  • Polymerase Chain Reaction
  • Tumor Virus Infections / genetics*
  • Tumor Virus Infections / pathology
  • Tumor Virus Infections / virology
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / virology

Substances

  • Amino Acids
  • DNA Primers
  • DNA, Viral
  • DNA-Binding Proteins
  • E2 protein, Human papillomavirus type 16
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Oncogene Proteins, Viral
  • oncogene protein E2, Human papillomavirus type 18