Treatment of methanol poisoning with intravenous 4-methylpyrazole

M J Burns; A Graudins; C K Aaron; K McMartin; J Brent

doi:10.1016/s0196-0644(97)70060-x

Treatment of methanol poisoning with intravenous 4-methylpyrazole

Ann Emerg Med. 1997 Dec;30(6):829-32. doi: 10.1016/s0196-0644(97)70060-x.

Authors

M J Burns¹, A Graudins, C K Aaron, K McMartin, J Brent

Affiliation

¹ Department of Emergency Medicine, University of Massachusetts Medical Center, Worcester, USA. mburns@bidmc.harvard.edu

PMID: 9398786
DOI: 10.1016/s0196-0644(97)70060-x

Abstract

Treatment of human methanol poisoning with the alcohol dehydrogenase inhibitor, 4-methylpyrazole (fomepizole), has not been previously described. We report the clinical and toxicokinetic data of a patient with methanol poisoning who was treated with fomepizole. Formic acid levels remained undetectable during fomepizole treatment, the toxic effects of methanol were prevented, and the patient made a full recovery.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Alcohol Dehydrogenase / antagonists & inhibitors*
Enzyme Inhibitors / pharmacokinetics
Enzyme Inhibitors / therapeutic use*
Fomepizole
Humans
Infusions, Intravenous
Male
Methanol / pharmacokinetics
Methanol / poisoning*
Poisoning / drug therapy
Pyrazoles / pharmacokinetics
Pyrazoles / therapeutic use*

Substances

Enzyme Inhibitors
Pyrazoles
Fomepizole
Alcohol Dehydrogenase
Methanol