A gene (ETM) for essential tremor maps to chromosome 2p22-p25

Mov Disord. 1997 Nov;12(6):859-64. doi: 10.1002/mds.870120605.


We report the results of linkage analysis in a large American family of Czech descent with dominantly inherited "pure" essential tremor (ET) and genetic anticipation. Genetic loci on chromosome 2p22-p25 establish linkage to this region with a maximum LOD score (Zmax) = 5.92 for the locus, D2S272. Obligate recombinant events place the ETM gene in a 15-cM candidate interval between the genetic loci D2S168 and D2S224. Repeat expansion detection analysis suggests that expanded CAG trinucleotide sequences are associated with ET. These findings will facilitate the search for an ETM gene and may further our understanding of the human motor system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Chromosome Aberrations / genetics*
  • Chromosome Disorders
  • Chromosomes, Human, Pair 2 / genetics*
  • Czech Republic / ethnology
  • Genetic Linkage / genetics
  • Haplotypes / genetics
  • Humans
  • Middle Aged
  • Pedigree
  • Phenotype
  • Severity of Illness Index
  • Tremor / diagnosis
  • Tremor / genetics*
  • Trinucleotide Repeats / genetics
  • United States
  • X Chromosome