Idiosyncratic adverse reactions to intramuscular botulinum toxin type A injection

Mov Disord. 1997 Nov;12(6):1064-7. doi: 10.1002/mds.870120637.


Three cases of adverse reactions to repeated intramuscular botulinum toxin A (BTA) injections are described: a persistent rash on the face at the site of injection, a localized anaphylactic reaction following BTA injection into one leg, and bilateral ptosis repeatedly following BTA injection into neck muscles. The mechanisms for these idiosyncratic adverse responses are not known.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / adverse effects*
  • Dystonia / drug therapy
  • Exanthema / etiology*
  • Female
  • Humans
  • Hypersensitivity*
  • Injections, Intramuscular
  • Middle Aged
  • Torticollis / drug therapy
  • Tremor / drug therapy


  • Botulinum Toxins, Type A