CCK biosynthesis and processing: recent progress and future challenges

Life Sci. 1997;61(24):2359-66. doi: 10.1016/s0024-3205(97)00644-9.


The peptide cholecystokinin (CCK), like other peptides which pass through the regulated secretory pathway, undergoes a number of post-translational modifications during its biosynthesis including tyrosine sulfation, endoproteolytic cleavage, and trimming by carboxypeptidases. This minireview summarizes what is known about this process in endocrine cells and in the Cpe(fat)/Cpe(fat) mouse and points out what challenges remain for future research.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholecystokinin / biosynthesis*
  • Cholecystokinin / metabolism
  • Humans
  • Mice
  • Organ Specificity
  • Protein Precursors / metabolism


  • Protein Precursors
  • procholecystokinin
  • Cholecystokinin