Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women

Am J Cardiol. 1997 Dec 1;80(11):1505-7. doi: 10.1016/s0002-9149(97)00732-7.

Abstract

To investigate the effect of estrogen with antioxidant potential on soluble markers of chronic vascular inflammation, we administered either transdermal 17beta-estradiol 0.1 mg/day (9 women) or 17beta-estradiol 0.1 mg and medroxyprogesterone acetate 2.5 mg/day (11 women) for 1-month treatment in a randomized design, with measurement of cell adhesion molecules. Hormone therapy significantly lowered intercellular adhesion molecules-1 levels by 8% (p = 0.009) and tended to lower E-selectin levels (by 6%, p = 0.096), and VCAM-1 levels (by 4%, p = 0.084).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Biomarkers / blood
  • Coronary Disease / blood
  • Coronary Disease / etiology
  • Coronary Disease / prevention & control
  • E-Selectin / blood
  • E-Selectin / drug effects
  • Estrogen Replacement Therapy*
  • Estrogens / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Intercellular Adhesion Molecule-1 / drug effects*
  • Lipoproteins / blood
  • Middle Aged
  • Postmenopause / blood*
  • Postmenopause / drug effects
  • Treatment Outcome
  • Vascular Cell Adhesion Molecule-1 / blood
  • Vascular Cell Adhesion Molecule-1 / drug effects*

Substances

  • Biomarkers
  • E-Selectin
  • Estrogens
  • Lipoproteins
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1