RARE imaging of PCr in human forearm muscles

J Magn Reson Imaging. Nov-Dec 1997;7(6):1048-55. doi: 10.1002/jmri.1880070617.

Abstract

Rapid acquisition with relaxation enhancement (RARE) sequences have been used to map the 31P phosphocreatine (PCr) signal in human forearms at 4.7 T. Signal-to-noise levels of approximately 10 were achieved from the major muscle groups in 5.5-minute scan times with a spatial resolution of 4 x 2 x 2 cm3. Exercise caused demonstrable reductions in PCr signal from activated muscles, which correlated with affected muscle groups in T2-weighted proton images. RARE imaging of the PCr signal at 4.7 T is feasible and, with technically achievable improvements in signal-to-noise ratio, should prove useful in studying energy metabolism in muscle and other organs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Forearm
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Muscle, Skeletal / chemistry*
  • Phantoms, Imaging
  • Phosphocreatine / analysis*

Substances

  • Phosphocreatine