Germline BRCA2 mutations in men with breast cancer

Br J Cancer. 1997;76(11):1428-31. doi: 10.1038/bjc.1997.574.


Breast cancer in men is rare and is clearly due in some cases to an inherited predisposition. A total of 28 male breast cancer patients were tested for BRCA2 mutations; two frameshifts and one putative missense mutation were identified. One of the frameshifts was detected in the same position as a mutation estimated to be responsible for 40% of all male breast cancer cases in Iceland.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • BRCA2 Protein
  • Base Sequence
  • Breast Neoplasms / genetics
  • Breast Neoplasms, Male / genetics*
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics
  • Female
  • Germ-Line Mutation*
  • Humans
  • Male
  • Neoplasm Proteins / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Transcription Factors / genetics*


  • BRCA2 Protein
  • DNA, Neoplasm
  • Neoplasm Proteins
  • Transcription Factors