Allelotype analysis of adenocarcinoma of the gastric cardia

Br J Cancer. 1997;76(11):1455-65. doi: 10.1038/bjc.1997.578.


To identify chromosomal loci involved in the development of proximal gastric adenocarcinoma, this study delineated the pattern of allelic imbalance in a series of 38 adenocarcinomas arising in the gastric cardia. A total of 137 microsatellite markers covering all autosomal arms, excluding acrocentric arms, were analysed. A mean of 35 out of a total of 39 chromosomal arms studied were informative for each patient. The tumour group demonstrated a high level of allelic imbalance, with an observed median fractional allelic imbalance of 0.47 for the 29 intestinal-type adenocarcinomas and 0.54 for the nine diffuse-type adenocarcinomas. Allelic imbalance was detected in >50% of informative cases in both histological subtypes on a number of chromosomal arms. In the intestinal subtype, these included, 3p (61%), 4q (71%), 5q (59%), 8p (60%), 9p (65%), 9q (83%), 12q (52%), 13q (52%), 17p (78%) and 18q (70%). A higher incidence of allelic imbalance was detected on chromosome 16q in tumours of the diffuse type relative to those of the intestinal type. A more detailed mapping on chromosomes 4q and 6q identified a number of cases with subchromosomal breakpoints. In conclusion, this analysis has indicated regions of the genome potentially involved in the development of proximal gastric carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology
  • Alleles*
  • Cardia
  • Chromosome Aberrations*
  • Chromosome Breakage
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4
  • Chromosomes, Human, Pair 6
  • DNA, Neoplasm / genetics
  • Genetic Markers
  • Humans
  • Microsatellite Repeats
  • Polymorphism, Genetic
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology


  • DNA, Neoplasm
  • Genetic Markers