Glomerulomegaly and proteinuria in a patient with idiopathic pulmonary hypertension

J Am Soc Nephrol. 1997 Dec;8(12):1966-70. doi: 10.1681/ASN.V8121966.


Glomerulomegaly is a histologic finding present in idiopathic pulmonary hypertension, congenital cyanotic heart disease, morbid obesity associated with sleep apnea syndrome, sickle cell disease, and polycythemic states. This study examines the case of a 34-yr-old woman with idiopathic pulmonary artery hypertension who presented with nephrotic-range proteinuria. Kidney biopsy revealed enlarged glomeruli with mesangial-proliferative glomerulonephritis. A review of the pertinent literature and a discussion of the proposed pathophysiologic mechanisms leading to glomerulomegaly are presented.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cardiomegaly / etiology
  • Cardiomegaly / physiopathology
  • Female
  • Glomerulonephritis, Membranoproliferative / etiology*
  • Glomerulonephritis, Membranoproliferative / physiopathology
  • Hemodynamics
  • Humans
  • Hypertension, Pulmonary / complications*
  • Hypertension, Pulmonary / physiopathology
  • Kidney Glomerulus / pathology*
  • Nephrotic Syndrome / etiology*
  • Obesity / complications
  • Proteinuria / etiology*