Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells

Leuk Lymphoma. 1997 Oct;27(3-4):247-56. doi: 10.3109/10428199709059681.


Protein tyrosine kinases (PTKs) mediate signals that respond to many pivotal cellular functions. Tyrosine phosphorylation, controlled by the coordinated actions of protein tyrosine phosphatases (PTPs) and PTKs, is a critical control mechanism for various physiological processes, including cell growth, differentiation, metabolism, cell cycle regulation and cytoskeleton function. The focal adhesion kinase (FAK) is a widely expressed non-receptor tyrosine kinase that is implicated in integrin-mediated signaling and plays a role in signal transduction pathways mediating cell adhesion, motility and anchorage-independent growth. Recently, we and others have identified a novel protein tyrosine kinase termed RAFTK, (also known as Pyk2 or Cak-beta), which is related to FAK. This review describes the role of RAFTK in various signaling cascades mainly in reference to hematopoietic cell lineages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Evolution
  • Cloning, Molecular
  • Conserved Sequence
  • Focal Adhesion Kinase 2
  • Hematopoietic Stem Cells / enzymology*
  • Humans
  • Integrins / physiology
  • Phosphorylation
  • Protein-Tyrosine Kinases / blood*
  • Protein-Tyrosine Kinases / genetics
  • Sequence Homology, Amino Acid


  • Integrins
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 2