Quinolone Arthropathy in Animals Versus Children

Clin Infect Dis. 1997 Nov;25(5):1196-204. doi: 10.1086/516119.


The use of quinolones in children and accumulation of data on the pharmacodynamics of these drugs have been limited and delayed by concern regarding their chondrotoxicity. A comprehensive review of the findings in animals compared with the cumulative published findings in children and adolescents (>7,000 to date) allows the conclusion that such concern is not justified. Prospective controlled studies in children are justifiable in view of a continuing lack of correlation between findings in juvenile animals and those in children and because of the selected therapeutic advantages of the current and newer quinolones.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Age Factors
  • Animals
  • Arthralgia / chemically induced
  • Cartilage / drug effects
  • Child
  • Growth
  • Humans
  • Joint Diseases / chemically induced*
  • Joint Diseases / physiopathology
  • Quinolones / adverse effects*
  • Quinolones / pharmacology


  • Quinolones