Synchronous occurrence of Wilms tumor and ganglioneuroblastoma in a child with neurofibromatosis

Eur J Pediatr Surg. 1997 Oct;7(5):308-10. doi: 10.1055/s-2008-1071180.


A 2-year-old male with neurofibromatosis who had a Wilms tumor of the right kidney and an ipsilateral adrenal ganglioneuroblastoma is reported. Both tumors were completely removed and no recurrence occurred for 4 years after completion of the therapy. In a review of the literature, the prognosis of neurofibromatosis with these embryonal tumors is not satisfactory due to development of secondary tumors and disseminated metastases of the tumors. The synchronous occurrence of Wilms tumor and neuroblastoma in neurofibromatosis is extremely rare and this may be the first report in the world.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms* / pathology
  • Adrenal Gland Neoplasms* / therapy
  • Child, Preschool
  • Diseases in Twins*
  • Ganglioneuroblastoma* / pathology
  • Ganglioneuroblastoma* / therapy
  • Humans
  • Kidney Neoplasms* / pathology
  • Kidney Neoplasms* / therapy
  • Male
  • Neoplasms, Multiple Primary* / pathology
  • Neoplasms, Multiple Primary* / therapy
  • Neurofibromatoses* / pathology
  • Neurofibromatoses* / therapy
  • Wilms Tumor* / pathology
  • Wilms Tumor* / therapy