Dendritic cell development: multiple pathways to nature's adjuvants

Stem Cells. 1997;15(6):409-19. doi: 10.1002/stem.150409.


Dendritic cells are a system of bone marrow-derived antigen-presenting cells specialized for interaction with T lymphocytes and essential for initiating primary T cell immune responses. Recent investigation indicates that dendritic cells are of diverse origin, with at least two types of myeloid precursors and a lymphoid precursor implicated in their generation. Mature dendritic cell subtypes, while sharing the capacity to activate T cells, show additional functional specialization. Some dendritic cells are equipped with additional mechanisms to regulate the response of the T cells they activate, while others are able to interact with B cells and modify B cell responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells
  • Cell Differentiation*
  • Dendritic Cells / cytology*
  • Dendritic Cells / immunology
  • Humans
  • Langerhans Cells / cytology
  • Models, Biological
  • Thymus Gland / cytology