Developmental Biology of Biofilms: Implications for Treatment and Control

Trends Microbiol. 1997 Nov;5(11):435-40. doi: 10.1016/S0966-842X(97)01142-6.


Although of heterogeneous spatiotemporal and species compositions, all biofilms undergo certain common developmental events: organic molecules on the substratum can play a role in initial attachment, attached cells grow and additional cells attach from the bulk liquid. Biofilm growth is a four-dimensional (X, Y, Z and T) process similar to organ development.

Publication types

  • Review

MeSH terms

  • Bacteria / cytology
  • Bacteria / growth & development
  • Bacterial Adhesion
  • Biofilms / growth & development*
  • Cell Division
  • Culture Media
  • Models, Biological
  • Surface Properties


  • Culture Media