White collar proteins: PASsing the light signal in Neurospora crassa

Trends Microbiol. 1997 Nov;5(11):458-62. doi: 10.1016/S0966-842X(97)01144-X.


The filamentous fungus Neurospora crassa is an excellent paradigm for the study of blue light signal transduction. The isolation and characterization of the genes for two central regulators of the blue light response, white collar-1 and white collar-2, have begun to shed light on the mechanism of blue light signal transduction in fungi. These proteins are not only proposed to encode blue-light-activated transcription factors but also to be elements of the blue light signal transduction pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Circadian Rhythm
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • DNA-Binding Proteins / radiation effects
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism*
  • Fungal Proteins / radiation effects
  • Genes, Fungal
  • Light
  • Mutation
  • Neurospora crassa / genetics
  • Neurospora crassa / metabolism*
  • Neurospora crassa / radiation effects*
  • Photobiology
  • Signal Transduction / radiation effects
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Transcription Factors / radiation effects


  • DNA-Binding Proteins
  • Fungal Proteins
  • Transcription Factors
  • wc-1 protein, Neurospora crassa
  • white collar 2 protein, Neurospora