Inactivation of human viruses by povidone-iodine in comparison with other antiseptics

Dermatology. 1997;195 Suppl 2:29-35. doi: 10.1159/000246027.

Abstract

Inactivation of a range of viruses, such as adeno-, mumps, rota-, polio- (types 1 and 3), coxsackie-, rhino-, herpes simplex, rubella, measles, influenza and human immunodeficiency viruses, by povidone-iodine (PVP-I) and other commercially available antiseptics in Japan was studied in accordance with the standardized protocol in vitro. In these experiments, antiseptics such as PVP-I solution, PVP-I gargle, PVP-I cream, chlorhexidine gluconate, alkyldiaminoethyl-glycine hydrochloride, benzalkonium chloride (BAC) and benzethonium chloride (BEC) were used. PVP-I was effective against all the virus species tested. PVP-I drug products, which were examined in these experiments, inactivated all the viruses within a short period of time. Rubella, measles, mumps viruses and HIV were sensitive to all of the antiseptics, and rotavirus was inactivated by BAC and BEC, while adeno-, polio- and rhinoviruses did not respond to the other antiseptics. PVP-I had a wider virucidal spectrum, covering both enveloped and nonenveloped viruses, than the other commercially available antiseptics.

Publication types

  • Comparative Study

MeSH terms

  • Adenoviridae / drug effects
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / pharmacology*
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / pharmacology*
  • Benzalkonium Compounds / administration & dosage
  • Benzalkonium Compounds / pharmacology
  • Benzethonium / administration & dosage
  • Benzethonium / pharmacology
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / analogs & derivatives
  • Chlorhexidine / pharmacology
  • DNA Viruses / drug effects*
  • Enterovirus / drug effects
  • Glycine / administration & dosage
  • Glycine / pharmacology
  • HIV / drug effects
  • Humans
  • Iodophors / administration & dosage
  • Iodophors / pharmacology*
  • Measles virus / drug effects
  • Mouthwashes
  • Mumps virus / drug effects
  • Ointments
  • Orthomyxoviridae / drug effects
  • Poliovirus / drug effects
  • Povidone-Iodine / administration & dosage
  • Povidone-Iodine / pharmacology*
  • RNA Viruses / drug effects*
  • Rhinovirus / drug effects
  • Rotavirus / drug effects
  • Rubella virus / drug effects
  • Simplexvirus / drug effects

Substances

  • Anti-Infective Agents, Local
  • Antiviral Agents
  • Benzalkonium Compounds
  • Iodophors
  • Mouthwashes
  • Ointments
  • Benzethonium
  • Povidone-Iodine
  • chlorhexidine gluconate
  • Chlorhexidine
  • Glycine