Effects of milk-borne colony stimulating factor-1 on circulating growth factor levels in the newborn infant

J Pediatr. 1997 Nov;131(5):748-50. doi: 10.1016/s0022-3476(97)70105-7.


Colony stimulating factor-1 (CSF-1) concentrations in colostrum were 20 to 25 times higher than in serum at birth and declined with lactation. No difference in concentrations of circulating CSF-1, however, were noted between breast-fed and formula-fed infants, suggesting that milk-borne CSF-1 may feed back negatively on endogenous growth factor levels, may act locally in the gastrointestinal tract, or may be locally degraded.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Female
  • Food, Formulated
  • Gestational Age
  • Growth Substances / blood*
  • Humans
  • Infant Nutritional Physiological Phenomena
  • Infant, Newborn
  • Macrophage Colony-Stimulating Factor / blood*
  • Male
  • Milk, Human / chemistry*
  • Radioimmunoassay


  • Growth Substances
  • Macrophage Colony-Stimulating Factor