Effect of short-term creatine supplementation on renal responses in men

Eur J Appl Physiol Occup Physiol. 1997;76(6):566-7. doi: 10.1007/s004210050291.


There is an increasing utilisation of oral creatine (Cr) supplementation among athletes who hope to enhance their performance but it is not known if this ingestion has any detrimental effect on the kidney. Five healthy men ingested either a placebo or 20 g of creatine monohydrate per day for 5 consecutive days. Blood samples and urine collections were analysed for Cr and creatinine (Crn) determination after each experimental session. Total protein and albumin urine excretion rates were also determined. Oral Cr supplementation had a significant incremental impact on arterial content (3.7 fold) and urine excretion rate (90 fold) of this compound. In contrast, arterial and urine Crn values were not affected by the Cr ingestion. The glomerular filtration rate (Crn clearance) and the total protein and albumin excretion rates remained within the normal range. In conclusion, this investigation showed that short-term oral Cr supplementation does not appear to have any detrimental effect on the renal responses of healthy men.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Albuminuria
  • Arteries
  • Creatine / adverse effects*
  • Creatine / blood
  • Creatine / urine
  • Creatinine / blood
  • Creatinine / urine
  • Glomerular Filtration Rate
  • Humans
  • Kidney / drug effects*
  • Kidney / physiology*
  • Male
  • Proteinuria


  • Creatinine
  • Creatine