Urinary excretion of TGF-beta 1, PDGF-BB and fibronectin in insulin-dependent diabetes mellitus patients

Kidney Int Suppl. 1997 Dec;63:S195-7.

Abstract

We studied the urinary excretion of transforming growth factor-beta 1 (TGF-beta 1), platelet-derived growth factor-BB (PDGF) and fibronectin (FN) in 104 patients (52 normoalbuminuric, 24 microalbuminuric, and 28 with overt diabetic nephropathy) with insulin-dependent diabetes mellitus (IDDM) of a long duration and in 30 non-diabetic controls. IDDM patients had higher urinary excretion of TGF-beta 1, PDGF and FN compared to controls. Urinary excretion of TGF-beta 1 and PDGF was elevated in all IDDM subgroups, while FN excretion was significantly increased only in patients with macroalbuminuria. Urinary excretion of TGF-beta 1 and FN did not differ between normoalbuminuric IDDM patients with long duration of diabetes, a group at low risk of ever developing diabetic nephropathy, and IDDM patients with incipient or overt diabetic nephropathy. Excretion of PDGF was significantly higher in patients with micro- and macroalbuminuria compared to normoalbuminuric patients, but there was a considerable overlap between the groups. In conclusion, although longitudinal follow-up studies are needed to further clarify the issue, our results in long-standing IDDM do not support a hypothesis of urinary excretion of TGF-beta 1, PDGF or FN to predict development of diabetic nephropathy.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Albuminuria / urine
  • Anticoagulants / urine*
  • Becaplermin
  • Diabetes Mellitus, Type 2 / urine*
  • Diabetic Nephropathies / urine
  • Female
  • Fibronectins / urine*
  • Humans
  • Male
  • Platelet-Derived Growth Factor / urine*
  • Proto-Oncogene Proteins c-sis
  • Recombinant Proteins / urine
  • Transforming Growth Factor beta / urine*

Substances

  • Anticoagulants
  • Fibronectins
  • Platelet-Derived Growth Factor
  • Proto-Oncogene Proteins c-sis
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • Becaplermin