The measurement of R2, R2* and R2' in HIV-infected patients using the prime sequence as a measure of brain iron deposition

Magn Reson Imaging. 1997;15(10):1113-9. doi: 10.1016/s0730-725x(97)00089-1.


Brain iron deposition was assessed at 1.5 T in the caudate nucleus, globus pallidus and frontal and parieto-occipital white matter in 28 human immunodeficiency virus (HIV)-infected patients and 15 control subjects with a new Partially Refocussed Interleaved Multi-Echo sequence by measuring 1/T2, 1/T2* and 1/T2' (i.e., R2, R2* and R2'). There were significant differences in the R2 and R2* of the caudate nucleus (p < 0.0001 and p < 0.05) and the R2, R2* and R2' of the globus pallidus (p < 0.01, p < 0.005 and p < 0.05) in HIV-infected patients compared to control subjects. There was a trend for higher values of R2, R2* and R2' in the globus pallidus and caudate nucleus in HIV-infected patients with later stage HIV disease. These results suggest that there is greater iron deposition in the basal ganglia of HIV-infected patients compared with control subjects, with a predilection for the globus pallidus. The relationship between iron deposition in the brain and various parameters of severity of HIV infection remains uncertain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Dementia Complex / metabolism*
  • AIDS Dementia Complex / pathology
  • Adult
  • Basal Ganglia / metabolism
  • Basal Ganglia / pathology
  • Brain / metabolism*
  • Brain / pathology
  • CD4 Lymphocyte Count
  • Caudate Nucleus / metabolism
  • Caudate Nucleus / pathology
  • Female
  • Globus Pallidus / metabolism
  • Globus Pallidus / pathology
  • Humans
  • Iron / metabolism*
  • Magnetic Resonance Imaging
  • Male


  • Iron