Development of systemic lupus erythematosus in a rheumatoid arthritis patient with anti-ribosomal P protein antibody

Lupus. 1997;6(9):734-6. doi: 10.1177/096120339700600910.


We describe a patient with rheumatoid arthritis (RA) whose sera contained a high titre of an antibody targeting cytoplasmic ribosomal P proteins (anti-P). This association preceded by 6 years the development of serological and clinical manifestations of systemic lupus erythematosus (SLE). The clinical significance of anti-P for the diagnosis of SLE is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / immunology
  • Autoantibodies / immunology*
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / etiology*
  • Lupus Erythematosus, Systemic / immunology
  • Protozoan Proteins*
  • Ribosomal Proteins / immunology*


  • Autoantibodies
  • L12E protein, Trypanosoma cruzi
  • Protozoan Proteins
  • Ribosomal Proteins